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名稱	Recombinant Murine M-CSF
型號(hào)
更新時(shí)間	2023-09-24
特點(diǎn)	M-CSF是一個(gè)有效的造血因子由多種細(xì)胞包括淋巴細(xì)胞、單核細(xì)胞、成纖維細(xì)胞、內(nèi)皮細(xì)胞、成肌細(xì)胞和成骨細(xì)胞。M-CSF臨床上用于治療感染,惡性腫瘤和動(dòng)脈粥樣硬化。它促進(jìn)骨髓移植后造血恢復(fù)。重組小鼠M-CSF是36.4 kDa homodimeric蛋白質(zhì)包含兩個(gè)156氨基酸多肽子單元。使用所有無動(dòng)物生產(chǎn)試劑。}

詳細(xì)內(nèi)容

一.產(chǎn)品名稱：Recombinant Murine M-CSF/Peprotech M-CSF

二.Catalog Number:AF-315-02

三.Synonyms:Macrophage Colony Stimulating Factor, CSF-1, MGI-IM

四.Description:

M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant murine M-CSF is a 36.4 kDa homodimeric protein containing two 156 amino acid polypeptide subunits. Manufactured using all non-animal reagents.

五.AA Sequence:

MKEVSEHCSH MIGNGHLKVL LIDSQMET SCQIAFEFVD QEQLDDPVCY LKKAFFLVQD IIDETMRFKD NTPNANATER LQELSNNLNS CFTKDYEEQN KACVRTFHET PLQLLEKIKN FFNETKNLLE KDWNIFTKNC NNSFAKCSSR DVVTKP

六.Source:E.coli

七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

八.Biological Activity:

Determined by its ability to stimulate the proliferation of murine M-NFS-60 cells. The expected ED₅₀ is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥1 x 10⁶ units/mg.

九.Cross Reactivity:Mouse, Rat