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名稱	Recombinant Human IL-1β
型號
更新時間	2023-09-24
特點(diǎn)	IL-1β是各種細(xì)胞的促炎細(xì)胞因子產(chǎn)生包括單核細(xì)胞、組織巨噬細(xì)胞,角質(zhì)細(xì)胞和其他上皮細(xì)胞。這些細(xì)胞因子刺激胸腺細(xì)胞增殖,誘導(dǎo)IL-2釋放,B-cell成熟和擴(kuò)散,促有絲分裂的FGF-like活動和刺激前列腺素的釋放和膠原酶從滑膜細(xì)胞。然而,IL-1β而IL-1β是分泌細(xì)胞因子主要是cell-associated細(xì)胞因子。重組人類IL-1β17.3 kDa蛋白質(zhì)含有153個氨基酸。}

詳細(xì)內(nèi)容

一.產(chǎn)品名稱：Recombinant Human IL-1β/Peprotech IL-1β

二.Catalog Number:AF-200-01B

三.Synonyms:Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)

四.Description:

IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1β is predominantly a cell-associated cytokine. Recombinant human IL-1β is a 17.3 kDa protein containing 153 amino acid residues. Manufactured using all non-animal reagents.

五.AA Sequence:

APVRSLNCTL RDSKSLVM SGPYELKALH LQGQDMEV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS

六.Source:E.coli

七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

八.Biological Activity:

Determined by its ability to stimulate the proliferation of mouse D10S cells. The expected ED₅₀ is ≤ 0.001 ng/ml, corresponding to a specific activity of ≥ 1 x 10⁹ units/mg.

九.Cross Reactivity:

Frog, Monkey, Mouse, Rabbit, Rat, Sheep, Human